| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase SYK |
|---|
| Ligand | BDBM247061 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Syk Enzyme Inhibition 1 |
|---|
| IC50 | 7.00±n/a nM |
|---|
| Citation |  Cariou, CA; Charron, CE; Fordyce, EA; Hamza, D; Fyfe, MC; Ito, K; King-Underwood, J; Murray, PJ; Onions, ST; Thom, SM; Watson, HT; Williams, JG Pyrazolyl-ureas as kinase inhibitors US Patent US9701670 Publication Date 7/11/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase SYK |
|---|
| Name: | Tyrosine-protein kinase SYK |
|---|
| Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 72079.99 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P43405 |
|---|
| Residue: | 635 |
|---|
| Sequence: | MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
|
|
|
|---|
| BDBM247061 |
|---|
| n/a |
|---|
| Name | BDBM247061 |
|---|
| Synonyms: | N-(2-(Dimethylamino)ethyl)-3-((4-((4-(3-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-5-methoxybenzamide | US9701670, 5 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C40H43N9O4 |
|---|
| Mol. Mass. | 713.8273 |
|---|
| SMILES | COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)cc(c1)C(=O)NCCN(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
