Reaction Details |
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Target | Glycogen synthase kinase-3 alpha |
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Ligand | BDBM247064 |
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Substrate/Competitor | n/a |
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Meas. Tech. | GSK 3alpha Enzyme Inhibition 1 |
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IC50 | 7950±n/a nM |
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Citation | Cariou, CA; Charron, CE; Fordyce, EA; Hamza, D; Fyfe, MC; Ito, K; King-Underwood, J; Murray, PJ; Onions, ST; Thom, SM; Watson, HT; Williams, JG Pyrazolyl-ureas as kinase inhibitors US Patent US9701670 Publication Date 7/11/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Glycogen synthase kinase-3 alpha |
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Name: | Glycogen synthase kinase-3 alpha |
Synonyms: | GSK-3 alpha | GSK3A | GSK3A_HUMAN | Glycogen synthase kinase 3 alpha (GSKalpha) | Glycogen synthase kinase-3 | Glycogen synthase kinase-3 alpha | Glycogen synthase kinase-3 alpha (GSK3 Alpha) | Glycogen synthase kinase-3 alpha (GSK3A) | Glycogen synthase kinase-3 alpha (GSK3alpha) |
Type: | Enzyme |
Mol. Mass.: | 50991.79 |
Organism: | Homo sapiens (Human) |
Description: | P49840 |
Residue: | 483 |
Sequence: | MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGV
GASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYT
DIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFY
SSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGV
CHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSS
IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIK
AHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLP
PLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLT
NSS
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BDBM247064 |
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n/a |
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Name | BDBM247064 |
Synonyms: | 3-((4-((4-(3-(3-Isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-5-methoxy-N-(2-morpholinoethyl)benzamide | US9701670, 8 |
Type | Small organic molecule |
Emp. Form. | C42H45N9O5 |
Mol. Mass. | 755.864 |
SMILES | COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)cc(c1)C(=O)NCCN1CCOCC1 |
Structure |
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