| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase BTK |
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| Ligand | BDBM324357 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro BTK Kinase Assay |
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| IC50 | 5.50±n/a nM |
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| Citation |  Hopkins, BT; Ma, B; Prince, R; Marx, I; Lyssikatos, JP Inhibiting agents for bruton's tyrosine kinase US Patent US10227341 Publication Date 3/12/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase BTK |
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| Name: | Tyrosine-protein kinase BTK |
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| Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) |
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| Type: | Enzyme |
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| Mol. Mass.: | 76289.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q06187 |
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| Residue: | 659 |
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| Sequence: | MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
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| BDBM324357 |
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| n/a |
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| Name | BDBM324357 |
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| Synonyms: | 5-(tert-butyl)-N-(7-(2- ((1-methyl-1H-pyrazol-4- yl)amino)pyrimidin-4- yl)-3-(oxetan-3-yl)- 2,3,4,5-tetrahydro-1H- benzo[d]azepin-1-yl)- 1,3,4-oxadiazole-2- carboxamide | US10189829, Compound 48 | US10227341, Compound 48 | US10961237, Compound 48 | US11858926, Compound 48 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H33N9O3 |
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| Mol. Mass. | 543.6201 |
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| SMILES | Cn1cc(Nc2nccc(n2)-c2ccc3C(CN(CCc3c2)C2COC2)NC(=O)c2nnc(o2)C(C)(C)C)cn1 |
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| Structure | 
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