Reaction Details |
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Target | Serine/threonine-protein kinase/endoribonuclease IRE1 |
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Ligand | BDBM160339 |
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Substrate/Competitor | n/a |
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Meas. Tech. | IRE-1alpha Assay |
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pH | 7.5±n/a |
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Temperature | 303.15±n/a K |
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IC50 | <100±n/a nM |
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EC50 | <10000±n/a nM |
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Comments | extracted |
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Citation | Zeng, Q; Toro, A; Patterson, JB; Wade, WS; Zubovics, Z; Yang, Y; Wu, Z IRE-1α inhibitors US Patent US9693992 Publication Date 7/4/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase/endoribonuclease IRE1 |
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Name: | Serine/threonine-protein kinase/endoribonuclease IRE1 |
Synonyms: | ERN1 | ERN1_HUMAN | Endoplasmic reticulum-to-nucleus signaling 1 | Endoribonuclease | IRE1 | IRE1a | Inositol requiring enzyme 1 (IRE-1alpha) | Inositol-requiring enzyme 1 (IRE1a) | Inositol-requiring protein 1 | Inositol-requiring protein 1 (IRE1a) | Ire1-alpha | Serine/threonine-protein kinase | Serine/threonine-protein kinase/endoribonuclease IRE1 | Serine/threonine-protein kinase/endoribonuclease IRE1 Alpha | hIRE1p |
Type: | Enzyme |
Mol. Mass.: | 109731.20 |
Organism: | Homo sapiens (Human) |
Description: | O75460 |
Residue: | 977 |
Sequence: | MPARRLLLLLTLLLPGLGIFGSTSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDP
VLQVPTHVEEPAFLPDPNDGSLYTLGSKNNEGLTKLPFTIPELVQASPCRSSDGILYMGK
KQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYF
DYAASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQREGLRKV
MHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMV
HEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDVKFDPGLKSKNKLNYLRNYWL
LIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKKSFEEVINLVDQTSENAPTTVSR
DVEEKPAHAPARPEAPVDSMLKDMATIILSTFLLIGWVAFIITYPLSMHQQQQLQHQQFQ
KELEKIQLLQQQQQQLPFHPPGDTAQDGELLDTSGPYSESSGTSSPSTSPRASNHSLCSG
SSASKAGSSPSLEQDDGDEETSVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKR
ILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAH
LGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAV
GRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQ
RQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQ
FFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDL
LRAMRNKKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPY
YFHEPPEPQPPVTPDAL
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BDBM160339 |
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n/a |
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Name | BDBM160339 |
Synonyms: | US9040714, 6 | US9693992, 6 |
Type | Small organic molecule |
Emp. Form. | C12H9BrO5 |
Mol. Mass. | 313.101 |
SMILES | COc1cc2c(C)c(Br)c(=O)oc2c(C=O)c1O |
Structure |
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