| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
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| Ligand | BDBM253649 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | MGAT LCMS Assay |
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| pH | 7.4±n/a |
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| IC50 | 1.50±n/a nM |
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| Comments | extracted |
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| Citation |  Meng, W; Zhao, G Dihydropyridinone MGAT2 inhibitors for use in the treatment of metabolic disorders US Patent US9701672 Publication Date 7/11/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
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| Name: | Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
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| Synonyms: | 2.4.1.143 | Beta-1,2-N-acetylglucosaminyltransferase II | GNT-II | GlcNAc-T II | MGAT2 | MGAT2_HUMAN | Mannoside acetylglucosaminyltransferase 2 | Monoacylglycerol acyltransferase 2 (MGAT2) | Monoacylglycerol acyltransferase type 2 (h-MGAT2) | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II | h-MGAT2 (human monoacylglycerol acyltransferase type 2) |
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| Type: | n/a |
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| Mol. Mass.: | 51567.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q10469 |
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| Residue: | 447 |
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| Sequence: | MRFRIYKRKVLILTLVVAACGFVLWSSNGRQRKNEALAPPLLDAEPARGAGGRGGDHPSV
AVGIRRVSNVSAASLVPAVPQPEADNLTLRYRSLVYQLNFDQTLRNVDKAGTWAPRELVL
VVQVHNRPEYLRLLLDSLRKAQGIDNVLVIFSHDFWSTEINQLIAGVNFCPVLQVFFPFS
IQLYPNEFPGSDPRDCPRDLPKNAALKLGCINAEYPDSFGHYREAKFSQTKHHWWWKLHF
VWERVKILRDYAGLILFLEEDHYLAPDFYHVFKKMWKLKQQECPECDVLSLGTYSASRSF
YGMADKVDVKTWKSTEHNMGLALTRNAYQKLIECTDTFCTYDDYNWDWTLQYLTVSCLPK
FWKVLVPQIPRIFHAGDCGMHHKKTCRPSTQSAQIESLLNNNKQYMFPETLTISEKFTVV
AISPPRKNGGWGDIRDHELCKSYRRLQ
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| BDBM253649 |
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| n/a |
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| Name | BDBM253649 |
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| Synonyms: | (S)—N-(4-(5-Ethylthiophen-2-yl)-2-oxo-6-(4-((6,6,6-trifluorohexyl)oxy)phenyl)-6-(trifluoromethyl)-1,2,5,6-tetrahydropyridin-3-yl)-2-(methylsulfonyl)acetamide | US9701672, 75 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H30F6N2O5S2 |
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| Mol. Mass. | 640.658 |
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| SMILES | CCc1ccc(s1)C1=C(NC(=O)CS(C)(=O)=O)C(=O)N[C@@](C1)(c1ccc(OCCCCCC(F)(F)F)cc1)C(F)(F)F |r,c:8| |
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| Structure | 
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