| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosylhomocysteinase |
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| Ligand | BDBM369458 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | S-Adenosylhomocysteine Hydrolase (SAHase) Inhibition |
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| IC50 | 0.900±n/a nM |
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| Citation |  Schneller, SW; Liu, C; Chen, Q; Ye, W Enantiomers of the 1′,6′-isomer of neplanocin A US Patent US10227373 Publication Date 3/12/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosylhomocysteinase |
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| Name: | Adenosylhomocysteinase |
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| Synonyms: | Adenosylhomocysteinase | S-Adenosylhomocysteine Hydrolase | SAHase |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 58521.01 |
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| Organism: | Oryctolagus cuniculus (Rabbit) |
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| Description: | n/a |
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| Residue: | 536 |
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| Sequence: | MKGTIMARCPLGKPSRRSIDSTGQNSESGAGIEVHSGHAPVRGPRPCRLSLSGTHEYAKR
GRYLKAPAPRADSCPAPPAQCLISALGLIPFSPVCITACSNAARMSDKLPYKVADIGLAA
WGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVQW
SSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNMILDDGGDLT
NLIHTKYPQLLSGIRGISEETTTGVHNLYKMMANGVLKVPAINVNDSVTKSKFDNLYGCR
ESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEG
YEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAV
EKVNIKPQVDRYWLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVLAQIELWTHP
DKYAVGVHFLPKKLDEAVAEAHLSKLNVKLTKLTEKQAQYLGMSRDGPFKPDHYRY
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| BDBM369458 |
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| n/a |
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| Name | BDBM369458 |
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| Synonyms: | US10227373, Compound D-Isoneplanocin |
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| Type | Small organic molecule |
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| Emp. Form. | C11H13N5O3 |
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| Mol. Mass. | 263.2526 |
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| SMILES | Nc1ncnc2n(cnc12)C1=C[C@H](CO)[C@@H](O)[C@H]1O |r,t:12| |
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| Structure | 
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