Ki Summary

Reaction Details

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Target

Diacylglycerol kinase zeta

Ligand

BDBM615870

Substrate/Competitor

n/a

Meas. Tech.

DGKalpha and DGKzeta Biochemical Assays

IC50

55±n/a nM

Citation

Casarez, A; Kellar, T COMPOUNDS USEFUL AS T CELL ACTIVATORS US Patent US20230271954 Publication Date 8/31/2023

More Info.:

Get all data from this article, Assay Method

Diacylglycerol kinase zeta

Name:

Diacylglycerol kinase zeta

Synonyms:

Type:

PROTEIN

Mol. Mass.:

124177.85

Organism:

Homo sapiens

Description:

ChEMBL_117547

Residue:

1117

Sequence:

METFFRRHFRGKVPGPGEGQQRPSSVGLPTGKARRRSPAGQASSSLAQRRRSSAQLQGCL
LSCGVRAQGSSRRRSSTVPPSCNPRFIVDKVLTPQPTTVGAQLLGAPLLLTGLVGMNEEE
GVQEDVVAEASSAIQPGTKTPGPPPPRGAQPLLPLPRYLRRASSHLLPADAVYDHALWGL
HGYYRRLSQRRPSGQHPGPGGRRASGTTAGTMLPTRVRPLSRRRQVALRRKAAGPQAWSA
LLAKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCY
VGEQYCVARMLKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVR
HHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCS
LGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSP
LMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILAC
GGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEG
NVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANP
EKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIP
RYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTT
SKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRV
SMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKL
SPKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLP
TSPCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAV
STGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQG
DTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV

BDBM615870

n/a

Name

BDBM615870

Synonyms:

US20230271954, Compound 169 | cis-8-((4-((cyclobutylmethyl)(2,3-dihydrobenzo[b] [1,4]dioxin-6-yl)amino)cyclohexyl)(methyl)amino)- 5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2- carbonitrile

Type

Small organic molecule

Emp. Form.

C30H35N5O3

Mol. Mass.

513.6306

SMILES

CN(C1CC[C@@H](CC1)N(CC1CCC1)c1ccc2OCCOc2c1)c1cc(=O)n(C)c2ccc(nc12)C#N |r,wU:5.8,(-2.28,-3.85,;-2.28,-2.31,;-.94,-1.54,;.39,-2.31,;1.72,-1.54,;1.72,,;.39,.77,;-.94,,;3.06,.77,;4.39,,;5.73,.77,;7.21,.37,;7.61,1.86,;6.12,2.26,;3.06,2.31,;4.39,3.08,;4.39,4.62,;3.06,5.39,;3.06,6.93,;1.72,7.7,;.39,6.93,;.39,5.39,;1.72,4.62,;1.72,3.08,;-3.61,-1.54,;-3.61,,;-4.94,.77,;-4.94,2.31,;-6.28,,;-7.61,.77,;-6.28,-1.54,;-7.61,-2.31,;-7.61,-3.85,;-6.28,-4.62,;-4.94,-3.85,;-4.94,-2.31,;-6.28,-6.16,;-6.28,-7.7,)|

Structure