| Reaction Details |
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 | Report a problem with these data |
| Target | DNA polymerase III subunit alpha |
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| Ligand | BDBM21686 |
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| Substrate/Competitor | BDBM21687 |
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| Meas. Tech. | DNA Polymerase Activity Assay |
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| pH | 7.5±n/a |
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| Temperature | 303.15±n/a K |
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| Ki | 117000±n/a nM |
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| Citation |  Butler, MM; Lamarr, WA; Foster, KA; Barnes, MH; Skow, DJ; Lyden, PT; Kustigian, LM; Zhi, C; Brown, NC; Wright, GE; Bowlin, TL Antibacterial activity and mechanism of action of a novel anilinouracil-fluoroquinolone hybrid compound. Antimicrob Agents Chemother51:119-27 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| DNA polymerase III subunit alpha |
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| Name: | DNA polymerase III subunit alpha |
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| Synonyms: | DNA polymerase III DnaE | DNA polymerase IIIE | DNA-directed DNA polymerase | DPO3A_BACSU | dnaE |
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| Type: | Enzyme |
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| Mol. Mass.: | 125346.94 |
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| Organism: | Bacillus subtilis |
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| Description: | Enzyme was purified from recombinant strains. |
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| Residue: | 1115 |
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| Sequence: | MSFVHLQVHSGYSLLNSAAAVEELVSEADRLGYASLALTDDHVMYGAIQFYKACKARGIN
PIIGLTASVFTDDSELEAYPLVLLAKSNTGYQNLLKISSVLQSKSKGGLKPKWLHSYREG
IIAITPGEKGYIETLLEGGLFEQAAQASLEFQSIFGKGAFYFSYQPFKGNQVLSEQILKL
SEETGIPVTATGDVHYIRKEDKAAYRCLKAIKAGEKLTDAPAEDLPDLDLKPLEEMQNIY
REHPEALQASVEIAEQCRVDVSLGQTRLPSFPTPDGTSADDYLTDICMEGLRSRFGKPDE
RYLRRLQYELDVIKRMKFSDYFLIVWDFMKHAHEKGIVTGPGRGSAAGSLVAYVLYITDV
DPIKHHLLFERFLNPERVSMPDIDIDFPDTRRDEVIQYVQQKYGAMHVAQIITFGTLAAK
AALRDVGRVFGVSPKEADQLAKLIPSRPGMTLDEARQQSPQLDKRLRESSLLQQVYSIAR
KIEGLPRHASTHAAGVVLSEEPLTDVVPLQEGHEGIYLTQYAMDHLEDLGLLKMDFLGLR
NLTLIESITSMIEKEENIKIDLSSISYSDDKTFSLLSKGDTTGIFQLESAGMRSVLKRLK
PSGLEDIVAVNALYRPGPMENIPLFIDRKHGRAPVHYPHEDLRSILEDTYGVIVYQEQIM
MIASRMAGFSLGEADLLRRAVSKKKKEILDRERSHFVEGCLKKEYSVDTANEVYDLIVKF
ANYGFNRSHAVAYSMIGCQLAYLKAHYPLYFMCGLLTSVIGNEDKISQYLYEAKGSGIRI
LPPSVNKSSFPFTVENGSVRYSLRAIKSVGVSAVKDIYKARKEKPFEDLFDFCFRVPSKS
VNRKMLEALIFSGAMDEFGQNRATLLASIDVALEHAELFAADDDQMGLFLDESFSIKPKY
VETEELPLVDLLAFEKETLGIYFSNHPLSAFRKQLTAQGAVSILQAQRAVKRQLSLGVLL
SKIKTIRTKTGQNMAFLTLSDETGEMEAVVFPEQFRQLSPVLREGALLFTAGKCEVRQDK
IQFIMSRAELLEDMDAEKAPSVYIKIESSQHSQEILAKIKRILLEHKGETGVYLYYERQK
QTIKLPESFHINADHQVLYRLKELLGQKNVVLKQW
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| BDBM21686 |
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| BDBM21687 |
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| Name | BDBM21686 |
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| Synonyms: | 3-(4-hydroxybutyl)-6-(3-ethyl-4-methylanilino)uracil | 6-[(3-ethyl-4-methylphenyl)amino]-3-(4-hydroxybutyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione | CHEMBL327687 | HB-EMAU | HBEMAU |
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| Type | Small organic molecule |
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| Emp. Form. | C17H23N3O3 |
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| Mol. Mass. | 317.3828 |
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| SMILES | CCc1cc(Nc2cc(=O)n(CCCCO)c(=O)[nH]2)ccc1C |
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| Structure | 
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