| Reaction Details |
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 | Report a problem with these data |
| Target | DNA polymerase alpha subunit B |
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| Ligand | BDBM21688 |
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| Substrate/Competitor | BDBM21687 |
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| Meas. Tech. | DNA Polymerase Activity Assay |
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| pH | 7.5±n/a |
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| Temperature | 310.15±n/a K |
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| Ki | >482000±n/a nM |
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| Citation |  Butler, MM; Lamarr, WA; Foster, KA; Barnes, MH; Skow, DJ; Lyden, PT; Kustigian, LM; Zhi, C; Brown, NC; Wright, GE; Bowlin, TL Antibacterial activity and mechanism of action of a novel anilinouracil-fluoroquinolone hybrid compound. Antimicrob Agents Chemother51:119-27 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| DNA polymerase alpha subunit B |
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| Name: | DNA polymerase alpha subunit B |
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| Synonyms: | 70 kD subunit | DNA Polymerase alpha | DNA polymerase alpha 70 kDa subunit | DNA polymerase alpha subunit B | DPOA2_BOVIN | POLA2 | Polymerase (DNA directed), alpha 2 |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 66940.74 |
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| Organism: | Bos taurus (bovine) |
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| Description: | Enzyme was purchased from Ulrich Hubscher, University of Zurich-Irchel, Switzerland. |
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| Residue: | 604 |
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| Sequence: | MAVSAQLLVEELQIFGLECEEAVIEKLVELCILYGQNEEGMASELIAFCTSTRKDCFTLE
TLNSFEHEFLSKRVSKTRHGASKDKGLRHAGARDIVSIQELIEVEEEEETLLNSYTTPSK
GSQKRTITTPETPLTKRSVSARSPHQLLSPSSFSPSATPPQKYSSRSNRGEVVTSFGSAQ
GVSWSGRGGASPLSLKVLGHPEPLTGSYKYMFQKLPDIREVLTCKIEELGSELKEHYKIE
AFAPILVPAQEPVTLLGQIGCDSNGKLNHKSVILEGDLEHSSGAQIPVDLSELKEYSLFP
GQVVVMEGINTTGRKLVATRLYEGVPLPFHQPDEEDGDSEQFMVLVACGPYTTSDSITFD
PLLDLITIINRDRPDVCILFGPFLDAKHEQVESCLLTSSFEDVFKQCLRTIIEGTRSSGS
HLIIVPSLRDVHHEPVYPQPPFSCSDLLREDKKRVRLVSEPCTLSINGVIFGLTSTDLLF
HMGAEEISSSSGTSDRFSRILRHILTQRSYYPLYPPQEDMAIDYENFYLYAQLPVTPDVF
IAPSELRYFVKVGLNSAISLQCQNQFLSGALALNSSRVCWWGQWPRSFGGGVGVENKSVS
IMLK
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| BDBM21688 |
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| BDBM21687 |
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| Name | BDBM21688 |
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| Synonyms: | 1-cyclopropyl-7-[4-(4-{4-[(3-ethyl-4-methylphenyl)amino]-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-1-yl}butyl)-3-methylpiperazin-1-yl]-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | 1-cyclopropyl-7-[4-(4-{4-[(3-ethyl-4-methylphenyl)amino]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}butyl)-3-methylpiperazin-1-yl]-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | 251D | CHEMBL201900 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H40F2N6O5 |
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| Mol. Mass. | 662.7261 |
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| SMILES | CCc1cc(Nc2cc(=O)n(CCCCN3CCN(CC3C)c3c(F)cc4c(c3F)n(cc(C(O)=O)c4=O)C3CC3)c(=O)[nH]2)ccc1C |
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| Structure | 
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