| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dipeptidyl peptidase 1 |
|---|
| Ligand | BDBM150609 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition of Human DPPI (Cathepsin C) |
|---|
| IC50 | 9.70±n/a nM |
|---|
| Citation |  Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Methods for treating pulmonary emphysema using substituted 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of Cathepsin C US Patent US10238633 Publication Date 3/26/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dipeptidyl peptidase 1 |
|---|
| Name: | Dipeptidyl peptidase 1 |
|---|
| Synonyms: | CATC_HUMAN | CPPI | CTSC | Cathepsin C | Cathepsin J | Dipeptidyl peptidase 1 (DDPI) | Dipeptidyl peptidase 1 (DPPI) | Dipeptidyl peptidase I | Dipeptidyl peptidase I (DPPI) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 51857.28 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P53634 |
|---|
| Residue: | 463 |
|---|
| Sequence: | MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQ
EKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNE
TMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINA
IQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNV
HGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEG
GFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALM
KLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGM
DYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL
|
|
|
|---|
| BDBM150609 |
|---|
| n/a |
|---|
| Name | BDBM150609 |
|---|
| Synonyms: | US10238633, Example 283 | US8987249, 283 | US9713606, 283 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H31FN4O2 |
|---|
| Mol. Mass. | 426.5269 |
|---|
| SMILES | Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)[C@@H]1CCN2CCOC[C@H]2C1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
