| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin K |
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| Ligand | BDBM150611 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition of Human Cathepsin K |
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| IC50 | 8700±n/a nM |
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| Citation |  Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Methods for treating pulmonary emphysema using substituted 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of Cathepsin C US Patent US10238633 Publication Date 3/26/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin K |
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| Name: | Cathepsin K |
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| Synonyms: | CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X |
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| Type: | Enzyme |
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| Mol. Mass.: | 36975.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43235 |
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| Residue: | 329 |
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| Sequence: | MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
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| BDBM150611 |
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| n/a |
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| Name | BDBM150611 |
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| Synonyms: | US10238633, Example 285 | US8987249, 285 | US9713606, 285 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19F4N5O |
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| Mol. Mass. | 421.3914 |
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| SMILES | Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cc(cn1)C(F)(F)F |r| |
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| Structure | 
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