| Reaction Details |
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 | Report a problem with these data |
| Target | Focal adhesion kinase 1 [410-689] |
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| Ligand | BDBM25121 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Activity Assay |
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| IC50 | 121±n/a nM |
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| Citation |  Luzzio, MJ; Freeman-Cook, KD; Bhattacharya, SK; Hayward, MM; Hulford, CA; Autry, CL; Zhao, X; Xiao, J; Nelson, KL Sulfonyl amide derivatives for the treatment of abnormal cell growth US Patent US10450297 Publication Date 10/22/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Focal adhesion kinase 1 [410-689] |
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| Name: | Focal adhesion kinase 1 [410-689] |
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| Synonyms: | FAK | FAK1 | FAK1_HUMAN | Focal adhesion kinase 1 (FAK) (aa 410-689) | PTK2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 32163.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 410-689 |
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| Residue: | 280 |
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| Sequence: | PSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFL
QEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQ
LSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWM
APESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPP
TLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEE
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| BDBM25121 |
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| n/a |
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| Name | BDBM25121 |
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| Synonyms: | 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide | BI 2536 | CHEMBL513909 | US10450297, Example 300 | US8598172, 5 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H39N7O3 |
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| Mol. Mass. | 521.6544 |
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| SMILES | CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O |r| |
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| Structure | 
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