Reaction Details |
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Target | Thymidine kinase |
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Ligand | BDBM21880 |
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Substrate/Competitor | BDBM21867 |
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Meas. Tech. | Thymidine Kinase Inhibition Assay |
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pH | 7.5±n/a |
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Temperature | 310.15±n/a K |
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IC50 | 5200±n/a nM |
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Km | 1000±n/a nM |
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Citation | Manikowski, A; Verri, A; Lossani, A; Gebhardt, BM; Gambino, J; Focher, F; Spadari, S; Wright, GE Inhibition of herpes simplex virus thymidine kinases by 2-phenylamino-6-oxopurines and related compounds: structure-activity relationships and antiherpetic activity in vivo. J Med Chem48:3919-29 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Thymidine kinase |
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Name: | Thymidine kinase |
Synonyms: | TK |
Type: | Transferase |
Mol. Mass.: | 40915.49 |
Organism: | Human herpesvirus 1 |
Description: | O72346 |
Residue: | 376 |
Sequence: | MASYPCHQHASAFDQAARSRGHSNRRTALRPRRQQEATEVRPEQKMPTLLRVYIDGPHGM
GKTTTTQLLVALGSRDDIVYVPEPMTYWRVLGASETIANIYTTQHRLDQGEISAGDAAVV
MTSAQITMGMPYAVTDAVLAPHIGGEAGSSHAPPPALTLIFDRHPIAALLCYPAARYLMG
SMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYG
LLANTVRYLQGGGSWREDWGQLSGTAVPPQGAEPQSNAGPRPHIGDTLFTLFRAPELLAP
NGDLYNVFAWALDVLAKRLRPMHVFILDYDQSPAGCRDALLQLTSGMVQTHVTTPGSIPT
ICDLARTFAREMGEAN
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BDBM21880 |
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BDBM21867 |
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Name | BDBM21880 |
Synonyms: | 2,9-disubstituted 6-oxopurine, 12d | 9-{4-[bis(2-hydroxyethyl)amino]butyl}-2-(phenylamino)-6,9-dihydro-3H-purin-6-one dihydrochloride |
Type | Small organic molecule |
Emp. Form. | C19H26N6O3 |
Mol. Mass. | 386.4481 |
SMILES | OCCN(CCO)CCCCn1cnc2c1nc(Nc1ccccc1)[nH]c2=O |
Structure |
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