Reaction Details |
| Report a problem with these data |
Target | Thymidine kinase |
---|
Ligand | BDBM21894 |
---|
Substrate/Competitor | BDBM21867 |
---|
Meas. Tech. | Thymidine Kinase Inhibition Assay |
---|
pH | 7.5±n/a |
---|
Temperature | 310.15±n/a K |
---|
IC50 | 410±n/a nM |
---|
Km | 1000±n/a nM |
---|
Citation | Manikowski, A; Verri, A; Lossani, A; Gebhardt, BM; Gambino, J; Focher, F; Spadari, S; Wright, GE Inhibition of herpes simplex virus thymidine kinases by 2-phenylamino-6-oxopurines and related compounds: structure-activity relationships and antiherpetic activity in vivo. J Med Chem48:3919-29 (2005) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Thymidine kinase |
---|
Name: | Thymidine kinase |
Synonyms: | TK |
Type: | Transferase |
Mol. Mass.: | 40915.49 |
Organism: | Human herpesvirus 1 |
Description: | O72346 |
Residue: | 376 |
Sequence: | MASYPCHQHASAFDQAARSRGHSNRRTALRPRRQQEATEVRPEQKMPTLLRVYIDGPHGM
GKTTTTQLLVALGSRDDIVYVPEPMTYWRVLGASETIANIYTTQHRLDQGEISAGDAAVV
MTSAQITMGMPYAVTDAVLAPHIGGEAGSSHAPPPALTLIFDRHPIAALLCYPAARYLMG
SMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYG
LLANTVRYLQGGGSWREDWGQLSGTAVPPQGAEPQSNAGPRPHIGDTLFTLFRAPELLAP
NGDLYNVFAWALDVLAKRLRPMHVFILDYDQSPAGCRDALLQLTSGMVQTHVTTPGSIPT
ICDLARTFAREMGEAN
|
|
|
BDBM21894 |
---|
BDBM21867 |
---|
Name | BDBM21894 |
Synonyms: | 1-{4-[6-oxo-2-(phenylamino)-6,9-dihydro-3H-purin-9-yl]butyl}-4-phenylpiperidine-4-carbonitrile dihydrochloride | 2,9-disubstituted 6-oxopurine, 12r |
Type | Small organic molecule |
Emp. Form. | C27H29N7O |
Mol. Mass. | 467.5655 |
SMILES | O=c1[nH]c(Nc2ccccc2)nc2n(CCCCN3CCC(CC3)(C#N)c3ccccc3)cnc12 |
Structure |
|