Reaction Details |
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Target | Receptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255] |
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Ligand | BDBM536906 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Potency Assessment EGFR (WT) and EGFR Mutants |
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IC50 | 4.30±n/a nM |
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Citation | Yang, Z; Zhang, X ErbB/BTK inhibitors US Patent US11896597 Publication Date 2/13/2024 |
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More Info.: | Get all data from this article, Assay Method |
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Receptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255] |
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Name: | Receptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255] |
Synonyms: | ERBB2 | ERBB2_HUMAN | HER2 | Her2 A775_G776insYVMA(YVMA) | MLN19 | NEU | NGL |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 138359.05 |
Organism: | Homo sapiens (Human) |
Description: | P04626[1-775,'YVMA',776-1255] |
Residue: | 1259 |
Sequence: | MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNL
ELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLA
LTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQC
AAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSAN
IQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLP
DLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQEC
VEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARC
PSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVG
ILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETEL
RKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAYVMAG
VGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYL
EDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILR
RRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMV
KCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGD
LVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLA
PSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQ
PEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEY
LTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV
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BDBM536906 |
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n/a |
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Name | BDBM536906 |
Synonyms: | US11896597, Compound 31 |
Type | Small organic molecule |
Emp. Form. | C31H41ClFN9O3 |
Mol. Mass. | 642.167 |
SMILES | COc1cc(N(C)CC2CCCN2CN(C)C)c(NC(=O)C=C)cc1Nc1ncnc(Nc2cc(Cl)c(F)cc2C(C)(C)O)n1 |
Structure |
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