| Reaction Details |
|---|
 | Report a problem with these data |
| Target | S-methyl-5'-thioadenosine phosphorylase |
|---|
| Ligand | BDBM22112 |
|---|
| Substrate/Competitor | BDBM22111 |
|---|
| Meas. Tech. | MTAP/MTAN Inhibition Assay |
|---|
| pH | 7±n/a |
|---|
| Temperature | 295.15±n/a K |
|---|
| Ki | 2.0±0.1 nM |
|---|
| Km | 5000±n/a nM |
|---|
| Citation |  Evans, GB; Furneaux, RH; Greatrex, B; Murkin, AS; Schramm, VL; Tyler, PC Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases. J Med Chem51:948-56 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| S-methyl-5'-thioadenosine phosphorylase |
|---|
| Name: | S-methyl-5'-thioadenosine phosphorylase |
|---|
| Synonyms: | 5'-Methylthioadenosine phosphorylase (MTAP) | MSAP | MTA phosphorylase | MTAP | MTAP_HUMAN | MTAPase | Methylthioadenosine Phosphorylase (MTAP) | S-methyl-5 -thioadenosine phosphorylase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 31239.23 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 283 |
|---|
| Sequence: | MASGTTTTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLAR
HGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMR
PQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSR
AESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTL
KENANKAKSLLLTTIPQIGSTEWSETLHNLKNMAQFSVLLPRH
|
|
|
|---|
| BDBM22112 |
|---|
| BDBM22111 |
|---|
| Name | BDBM22112 |
|---|
| Synonyms: | 7-({3-[(methylsulfanyl)methyl]azetidin-1-yl}methyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine | Azetidine based compound, 44 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C12H17N5S |
|---|
| Mol. Mass. | 263.362 |
|---|
| SMILES | CSCC1CN(Cc2c[nH]c3c(N)ncnc23)C1 |
|---|
| Structure | 
|
|---|
Search and Browse
