Ki Summary

Reaction Details

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Target

Receptor-interacting serine/threonine-protein kinase 2

Ligand

BDBM372161

Substrate/Competitor

n/a

Meas. Tech.

RIPK2 Inhibition Assay

IC50

>500±n/a nM

Citation

Laufer, R; Ng, G; Brokx, R; Pauls, HW; Li, S; Mason, JM; Bray, MR RIPK2 inhibitors and method of treating cancer with same US Patent US10239881 Publication Date 3/26/2019

More Info.:

Get all data from this article, Assay Method

Receptor-interacting serine/threonine-protein kinase 2

Name:

Receptor-interacting serine/threonine-protein kinase 2

Synonyms:

Type:

Protein

Mol. Mass.:

61201.30

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

540

Sequence:

MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSER
KDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPL
RFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRS
SKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMY
SVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEI
TFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPET
SRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIIN
PLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTK
PTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM

BDBM372161

n/a

Name

BDBM372161

Synonyms:

N-(3- morpholino- phenyl)-6- (tetrahydro-2H- pyran-4-yl)- 5H-pyrrolo[3,2-d] pyrimidin-2-amine | US10239881, Example A14 | US10875863, Example A14

Type

Small organic molecule

Emp. Form.

C21H25N5O2

Mol. Mass.

379.4555

SMILES

C1CC(CCO1)c1cc2nc(Nc3cccc(c3)N3CCOCC3)ncc2[nH]1

Structure