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TargetReceptor-interacting serine/threonine-protein kinase 2
LigandBDBM372165
Substrate/Competitorn/a
Meas. Tech.RIPK2 Inhibition Assay
IC50<100±n/a nM
Citation Laufer, R; Ng, G; Brokx, R; Pauls, HW; Li, S; Mason, JM; Bray, MR RIPK2 inhibitors and method of treating cancer with same US Patent US10239881 Publication Date 3/26/2019
More Info.:Get all data from this article,  Assay Method
 
Receptor-interacting serine/threonine-protein kinase 2
Name:Receptor-interacting serine/threonine-protein kinase 2
Synonyms:CARDIAK | RICK | RIP2 | RIPK2 | RIPK2_HUMAN | Serine/threonine-protein kinase RIPK2 | Tyrosine-protein kinase RIPK2 | receptor-interacting serine/threonine-protein kinase 2
Type:Protein
Mol. Mass.:61201.30
Organism:Homo sapiens (Human)
Description:n/a
Residue:540
Sequence:
MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSER
KDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPL
RFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRS
SKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMY
SVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEI
TFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPET
SRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIIN
PLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTK
PTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM372165
n/a
NameBDBM372165
Synonyms:N-(4-((4- methylpiperazin-1- yl)methyl)phenyl)- 6-(o-tolyl)-5H- pyrrolo[3,2-d] pyrimidin-2-amine | US10239881, Example A18 | US10875863, Example A18
TypeSmall organic molecule
Emp. Form.C25H28N6
Mol. Mass.412.53
SMILESCN1CCN(Cc2ccc(Nc3ncc4[nH]c(cc4n3)-c3ccccc3C)cc2)CC1
Structure
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