Ki Summary

Reaction Details

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Target

Receptor-interacting serine/threonine-protein kinase 2

Ligand

BDBM372168

Substrate/Competitor

n/a

Meas. Tech.

RIPK2 Inhibition Assay

IC50

300±n/a nM

Citation

Laufer, R; Ng, G; Brokx, R; Pauls, HW; Li, S; Mason, JM; Bray, MR RIPK2 inhibitors and method of treating cancer with same US Patent US10239881 Publication Date 3/26/2019

More Info.:

Get all data from this article, Assay Method

Receptor-interacting serine/threonine-protein kinase 2

Name:

Receptor-interacting serine/threonine-protein kinase 2

Synonyms:

Type:

Protein

Mol. Mass.:

61201.30

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

540

Sequence:

MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSER
KDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPL
RFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRS
SKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMY
SVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEI
TFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPET
SRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIIN
PLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTK
PTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM

BDBM372168

n/a

Name

BDBM372168

Synonyms:

(1r,4)-4-((6- (o-tolyl)- 5H-pyrrolo[3,2- d]pyrimidin-2- yl)amino) cyclohexanol | US10239881, Example A21 | US10239881, Example A22 | US10875863, Example A22

Type

Small organic molecule

Emp. Form.

C19H22N4O

Mol. Mass.

322.4042

SMILES

Cc1ccccc1-c1cc2nc(N[C@@H]3CC[C@H](O)CC3)ncc2[nH]1 |r,wU:13.13,16.17,(5.08,-2.1,;5.85,-.77,;7.39,-.77,;8.16,.56,;7.39,1.9,;5.85,1.9,;5.08,.56,;3.54,.56,;2.64,-.68,;1.17,-.21,;-.16,-.98,;-1.49,-.21,;-2.83,-.98,;-4.16,-.21,;-4.16,1.33,;-5.5,2.1,;-6.83,1.33,;-8.16,2.1,;-6.83,-.21,;-5.5,-.98,;-1.49,1.33,;-.16,2.1,;1.17,1.33,;2.64,1.81,)|

Structure