Reaction Details |
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Target | Lipoxygenase |
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Ligand | BDBM22363 |
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Substrate/Competitor | BDBM22231 |
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Meas. Tech. | COX Inhibitor Screening Assay |
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IC50 | >10000±n/a nM |
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Citation | Rao, PN; Chen, QH; Knaus, EE Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: dual inhibitors of cyclooxygenases and lipoxygenases. J Med Chem49:1668-83 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Lipoxygenase |
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Name: | Lipoxygenase |
Synonyms: | 5-Lipoxygenase | 5-Lipoxygenase (5-LO) |
Type: | Enzyme |
Mol. Mass.: | 97294.59 |
Organism: | Solanum tuberosum (potato) |
Description: | n/a |
Residue: | 864 |
Sequence: | MNIGQIMGGRELFGGHDDSKKVKGTVVMMKKNALDFTDLAGSLTDIAFDVLGQKVSFQLI
SSVQGDPTNGLQGKHSNPAYLENSLFTLTPLTAGSETAFGVTFDWNEEFGVPGAFIIKNT
HINEFFLKSLTLEDVPNHGKVHFDCNSWVYPSFRYKSDRIFFANQPYLPSKTPELLRKYR
ENELLTLRGDGTGKREAWDRIYDYDIYNDLGNPDQGKENVRTTLGGSAEYPYPRRGRTGR
PPTRTDPKSESRIPLLLSLDIYVPRDERFGHLKMSDFLTYALKSIVQFILPELHALFDGT
PNEFDSFEDVLRLYEGGIKLPQGPLFKALTAAIPLEMIKELLRTDGEGILRFPTPLVIKD
SKTAWRTDEEFAREMLAGVNPIIISRLQEFPPKSKLDPEAYGNQNSTITAEHIEDKLDGL
TVDEAMNNNKLFILNHHDLLIPYLRRINTTITKSYASRTLLFLQDNGSLKPLAIELSLPH
PDGDQFGVTSKVYTPSDQGVESSIWQLAKAYVAVNDAGVHQLISHWLNTHAVIEPFVIAT
NRQLSVLHPIHKLLYPHFRDTMNINASARQILINAGGVLESTVFQSKFALEMSAVVYKDW
VFPDQALPADLVKRGVAVEDSSSPHGVRLLIEDYPYAVDGLEIWSAIKSWVTDYCSFYYG
SDEEILKDNELQAWWKELREVGHGDKKNEPWWPEMETPQELIDSCTTIIWIASALHAAVN
FGQYPYAGYLPNRPTVSRRFMPEPGTPEYEELKKNPDKAFLKTITAQLQTLLGVSLVEIL
SRHTTDEIYLGQRESPEWTKDKEPLAAFDKFGKKLTDIEKQIIQRNGDNILTNRSGPVNA
PYTLLFPTSEGGLTGKGIPNSVSI
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BDBM22363 |
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BDBM22231 |
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Name | BDBM22363 |
Synonyms: | 1,3-Diarylprop-2-yn-1-one, 17c | 3-(4-methanesulfonylphenyl)-1-(4-methoxynaphthalen-1-yl)prop-2-yn-1-one |
Type | Small organic molecule |
Emp. Form. | C21H16O4S |
Mol. Mass. | 364.414 |
SMILES | COc1ccc(C(=O)C#Cc2ccc(cc2)S(C)(=O)=O)c2ccccc12 |
Structure |
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