Reaction Details |
| Report a problem with these data |
Target | Lipoxygenase |
---|
Ligand | BDBM22370 |
---|
Substrate/Competitor | BDBM22231 |
---|
Meas. Tech. | COX Inhibitor Screening Assay |
---|
IC50 | 320±n/a nM |
---|
Citation | Rao, PN; Chen, QH; Knaus, EE Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: dual inhibitors of cyclooxygenases and lipoxygenases. J Med Chem49:1668-83 (2006) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Lipoxygenase |
---|
Name: | Lipoxygenase |
Synonyms: | 5-Lipoxygenase | 5-Lipoxygenase (5-LO) |
Type: | Enzyme |
Mol. Mass.: | 97294.59 |
Organism: | Solanum tuberosum (potato) |
Description: | n/a |
Residue: | 864 |
Sequence: | MNIGQIMGGRELFGGHDDSKKVKGTVVMMKKNALDFTDLAGSLTDIAFDVLGQKVSFQLI
SSVQGDPTNGLQGKHSNPAYLENSLFTLTPLTAGSETAFGVTFDWNEEFGVPGAFIIKNT
HINEFFLKSLTLEDVPNHGKVHFDCNSWVYPSFRYKSDRIFFANQPYLPSKTPELLRKYR
ENELLTLRGDGTGKREAWDRIYDYDIYNDLGNPDQGKENVRTTLGGSAEYPYPRRGRTGR
PPTRTDPKSESRIPLLLSLDIYVPRDERFGHLKMSDFLTYALKSIVQFILPELHALFDGT
PNEFDSFEDVLRLYEGGIKLPQGPLFKALTAAIPLEMIKELLRTDGEGILRFPTPLVIKD
SKTAWRTDEEFAREMLAGVNPIIISRLQEFPPKSKLDPEAYGNQNSTITAEHIEDKLDGL
TVDEAMNNNKLFILNHHDLLIPYLRRINTTITKSYASRTLLFLQDNGSLKPLAIELSLPH
PDGDQFGVTSKVYTPSDQGVESSIWQLAKAYVAVNDAGVHQLISHWLNTHAVIEPFVIAT
NRQLSVLHPIHKLLYPHFRDTMNINASARQILINAGGVLESTVFQSKFALEMSAVVYKDW
VFPDQALPADLVKRGVAVEDSSSPHGVRLLIEDYPYAVDGLEIWSAIKSWVTDYCSFYYG
SDEEILKDNELQAWWKELREVGHGDKKNEPWWPEMETPQELIDSCTTIIWIASALHAAVN
FGQYPYAGYLPNRPTVSRRFMPEPGTPEYEELKKNPDKAFLKTITAQLQTLLGVSLVEIL
SRHTTDEIYLGQRESPEWTKDKEPLAAFDKFGKKLTDIEKQIIQRNGDNILTNRSGPVNA
PYTLLFPTSEGGLTGKGIPNSVSI
|
|
|
BDBM22370 |
---|
BDBM22231 |
---|
Name | BDBM22370 |
Synonyms: | 1,3-Diarylprop-2-yn-1-one, 27 | 3-(4-methanesulfonylphenyl)-1-[4-(methylsulfanyl)phenyl]prop-2-yn-1-one |
Type | Small organic molecule |
Emp. Form. | C17H14O3S2 |
Mol. Mass. | 330.421 |
SMILES | CSc1ccc(cc1)C(=O)C#Cc1ccc(cc1)S(C)(=O)=O |
Structure |
|