| Reaction Details |
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 | Report a problem with these data |
| Target | RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] |
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| Ligand | BDBM210021 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Time-Resolved Fluorescence Energy Transfer Assay |
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| IC50 | <0.250±n/a nM |
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| Citation |  Zhou, C; Wang, S; Zhang, G Fused tricyclic compounds as Raf kinase inhibitors US Patent US9895376 Publication Date 2/20/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] |
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| Name: | RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] |
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| Synonyms: | C-RAF (Y340D Y341D) | RAF | RAF proto-oncogene serine/threonine-protein kinase (Y340D/Y341D) | RAF proto-oncogene serine/threonine-protein kinase (c-Raf)(Y340D)(Y341D) | RAF1 | RAF1_HUMAN |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 72984.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P04049 Y340D Y341D |
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| Residue: | 648 |
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| Sequence: | MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSDDWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
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| BDBM210021 |
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| n/a |
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| Name | BDBM210021 |
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| Synonyms: | US10576087, Compound 2.27 | US9273046, 2.27 | US9895376, Compound 2.27 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H18N4O4 |
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| Mol. Mass. | 426.4241 |
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| SMILES | Oc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12 |
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| Structure | 
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