| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Epidermal growth factor receptor [1-751,753-758,760-1210] |
|---|
| Ligand | BDBM373708 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Kinase assay |
|---|
| Kd | 50±n/a nM |
|---|
| Citation |  Mansour, TS 1,2-dithiolane and dithiol compounds useful in treating mutant EGFR-mediated diseases and conditions US Patent US10246444 Publication Date 4/2/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Epidermal growth factor receptor [1-751,753-758,760-1210] |
|---|
| Name: | Epidermal growth factor receptor [1-751,753-758,760-1210] |
|---|
| Synonyms: | EGFR | EGFR S752-I759del | EGFR_HUMAN | ERBB | ERBB1 | HER1 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 134079.35 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P00533[1-751,753-758,760-1210] |
|---|
| Residue: | 1208 |
|---|
| Sequence: | MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVV
ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATPKANKELDEAYVMASVDNPHVCRLLGICL
TSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARN
VLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGV
TVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFR
ELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQG
FFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSI
DDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTV
QPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAP
QSSEFIGA
|
|
|
|---|
| BDBM373708 |
|---|
| n/a |
|---|
| Name | BDBM373708 |
|---|
| Synonyms: | US10246444, Example 85 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H28ClFN4O5S2 |
|---|
| Mol. Mass. | 655.159 |
|---|
| SMILES | OC[C@H](O)COc1cc2ncc(C#N)c(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2cc1NC(=O)C[C@@H]1CCSS1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
