| Reaction Details |
|---|
 | Report a problem with these data |
| Target | C-C chemokine receptor type 4 |
|---|
| Ligand | BDBM374665 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Ca Flux assay |
|---|
| IC50 | 300±n/a nM |
|---|
| Citation |  Beck, HP; Biannic, B; Bui, MH; Hu, DX; Jackson, JJ; Ketcham, JM; Powers, JP; Reilly, MK; Robles-Resendiz, O; Shunatona, HP; Walker, JR; Wustrow, DJ; Younai, A; Zibinsky, M Chemokine receptor modulators and uses thereof US Patent US10246462 Publication Date 4/2/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| C-C chemokine receptor type 4 |
|---|
| Name: | C-C chemokine receptor type 4 |
|---|
| Synonyms: | C-C CKR-4 | C-C chemokine receptor type 4 | C-C chemokine receptor type 4 (CCR4) | CC-CKR-4 | CCR-4 | CCR4 | CCR4_HUMAN | CD_antigen=CD194 | CMKBR4 | K5-5 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 41406.41 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P51679 |
|---|
| Residue: | 360 |
|---|
| Sequence: | MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVV
VLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVG
FYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYT
ERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKA
VKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLN
PIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
|
|
|
|---|
| BDBM374665 |
|---|
| n/a |
|---|
| Name | BDBM374665 |
|---|
| Synonyms: | 4-((2S)-1-(1-(1-((R)-1-(2,4-Dichlorophenyl)ethyl)-3-methyl-1H-pyrazolo[3,4-b]pyrazin-6-yl)-3-methylpiperidin-4-yl)pyrrolidin-2-yl)-1,1,1-trifluorobutan-2-ol hydrochloride | US10246462, Example 46 | US10246462, Example 47 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H35Cl2F3N6O |
|---|
| Mol. Mass. | 599.518 |
|---|
| SMILES | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CCC(C(C)C1)N1CCC[C@H]1CCC(O)C(F)(F)F |r| |
|---|
| Structure | 
|
|---|
Search and Browse
