| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 4 |
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| Ligand | BDBM374679 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Ca Flux assay |
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| IC50 | 300±n/a nM |
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| Citation |  Beck, HP; Biannic, B; Bui, MH; Hu, DX; Jackson, JJ; Ketcham, JM; Powers, JP; Reilly, MK; Robles-Resendiz, O; Shunatona, HP; Walker, JR; Wustrow, DJ; Younai, A; Zibinsky, M Chemokine receptor modulators and uses thereof US Patent US10246462 Publication Date 4/2/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 4 |
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| Name: | C-C chemokine receptor type 4 |
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| Synonyms: | C-C CKR-4 | C-C chemokine receptor type 4 | C-C chemokine receptor type 4 (CCR4) | CC-CKR-4 | CCR-4 | CCR4 | CCR4_HUMAN | CD_antigen=CD194 | CMKBR4 | K5-5 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41406.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51679 |
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| Residue: | 360 |
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| Sequence: | MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVV
VLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVG
FYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYT
ERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKA
VKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLN
PIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
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| BDBM374679 |
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| n/a |
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| Name | BDBM374679 |
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| Synonyms: | 3-((2S)-1-(1-(1-((R)-1-(2,4-Dichlorophenyl)ethyl)-3-methyl-1H-pyrazolo[3,4-b]pyrazin-6-yl)-3-methylpiperidin-4-yl)pyrrolidin-2-yl)butanoic acid 2,2,2-trifluoroacetate | US10246462, Example 60 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H36Cl2N6O2 |
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| Mol. Mass. | 559.53 |
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| SMILES | CC(CC(O)=O)[C@@H]1CCCN1C1CCN(CC1C)c1cnc2c(C)nn([C@H](C)c3ccc(Cl)cc3Cl)c2n1 |r| |
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| Structure | 
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