| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Equilibrative nucleoside transporter 1 |
|---|
| Ligand | BDBM23623 |
|---|
| Substrate/Competitor | BDBM23618 |
|---|
| Meas. Tech. | Flow Cytometric Assay |
|---|
| pH | 7.4±n/a |
|---|
| Temperature | 295.15±n/a K |
|---|
| Comments | 19.3 +/- 1.1 % Inhibition @ 10 uM. |
|---|
| Citation |  Lin, W; Buolamwini, JK Synthesis, flow cytometric evaluation, and identification of highly potent dipyridamole analogues as equilibrative nucleoside transporter 1 inhibitors. J Med Chem50:3906-20 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Equilibrative nucleoside transporter 1 |
|---|
| Name: | Equilibrative nucleoside transporter 1 |
|---|
| Synonyms: | ENT1 | Equilibrative NBMPR-sensitive nucleoside transporter | Equilibrative Nucleoside Transporter 1 (ENT1) | Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter | Equilibrative nucleoside transporter 1 | Nucleoside transporter, es-type | S29A1_HUMAN | SLC29A1 | Solute carrier family 29 member 1 |
|---|
| Type: | Multi-pass membrane protein |
|---|
| Mol. Mass.: | 50225.92 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 456 |
|---|
| Sequence: | MTTSHQPQDRYKAVWLIFFMLGLGTLLPWNFFMTATQYFTNRLDMSQNVSLVTAELSKDA
QASAAPAAPLPERNSLSAIFNNVMTLCAMLPLLLFTYLNSFLHQRIPQSVRILGSLVAIL
LVFLITAILVKVQLDALPFFVITMIKIVLINSFGAILQGSLFGLAGLLPASYTAPIMSGQ
GLAGFFASVAMICAIASGSELSESAFGYFITACAVIILTIICYLGLPRLEFYRYYQQLKL
EGPGEQETKLDLISKGEEPRAGKEESGVSVSNSQPTNESHSIKAILKNISVLAFSVCFIF
TITIGMFPAVTVEVKSSIAGSSTWERYFIPVSCFLTFNIFDWLGRSLTAVFMWPGKDSRW
LPSLVLARLVFVPLLLLCNIKPRRYLTVVFEHDAWFIFFMAAFAFSNGYLASLCMCFGPK
KVKPAEAETAGAIMAFFLCLGLALGAVFSFLFRAIV
|
|
|
|---|
| BDBM23623 |
|---|
| BDBM23618 |
|---|
| Name | BDBM23623 |
|---|
| Synonyms: | 2-({6-[(2-hydroxyethyl)amino]-4,8-bis(pyrrolidin-1-yl)pyrimido[5,4-d][1,3]diazin-2-yl}amino)ethan-1-ol | Dipyridamole Analogue, 3 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H28N8O2 |
|---|
| Mol. Mass. | 388.4673 |
|---|
| SMILES | OCCNc1nc(N2CCCC2)c2nc(NCCO)nc(N3CCCC3)c2n1 |
|---|
| Structure | 
|
|---|
Search and Browse
