| Reaction Details |
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 | Report a problem with these data |
| Target | Equilibrative nucleoside transporter 1 |
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| Ligand | BDBM23627 |
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| Substrate/Competitor | BDBM23618 |
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| Meas. Tech. | Flow Cytometric Assay |
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| pH | 7.4±n/a |
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| Temperature | 295.15±n/a K |
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| Comments | 44.6 +/- 2.1 % Inhibition @ 10 uM. |
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| Citation |  Lin, W; Buolamwini, JK Synthesis, flow cytometric evaluation, and identification of highly potent dipyridamole analogues as equilibrative nucleoside transporter 1 inhibitors. J Med Chem50:3906-20 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Equilibrative nucleoside transporter 1 |
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| Name: | Equilibrative nucleoside transporter 1 |
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| Synonyms: | ENT1 | Equilibrative NBMPR-sensitive nucleoside transporter | Equilibrative Nucleoside Transporter 1 (ENT1) | Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter | Equilibrative nucleoside transporter 1 | Nucleoside transporter, es-type | S29A1_HUMAN | SLC29A1 | Solute carrier family 29 member 1 |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 50225.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 456 |
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| Sequence: | MTTSHQPQDRYKAVWLIFFMLGLGTLLPWNFFMTATQYFTNRLDMSQNVSLVTAELSKDA
QASAAPAAPLPERNSLSAIFNNVMTLCAMLPLLLFTYLNSFLHQRIPQSVRILGSLVAIL
LVFLITAILVKVQLDALPFFVITMIKIVLINSFGAILQGSLFGLAGLLPASYTAPIMSGQ
GLAGFFASVAMICAIASGSELSESAFGYFITACAVIILTIICYLGLPRLEFYRYYQQLKL
EGPGEQETKLDLISKGEEPRAGKEESGVSVSNSQPTNESHSIKAILKNISVLAFSVCFIF
TITIGMFPAVTVEVKSSIAGSSTWERYFIPVSCFLTFNIFDWLGRSLTAVFMWPGKDSRW
LPSLVLARLVFVPLLLLCNIKPRRYLTVVFEHDAWFIFFMAAFAFSNGYLASLCMCFGPK
KVKPAEAETAGAIMAFFLCLGLALGAVFSFLFRAIV
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| BDBM23627 |
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| BDBM23618 |
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| Name | BDBM23627 |
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| Synonyms: | Dipyridamole Analogue, 7 | tert-butyl 4-{2,6-bis[bis(2-hydroxyethyl)amino]-8-{4-[(tert-butoxy)carbonyl]piperazin-1-yl}pyrimido[5,4-d][1,3]diazin-4-yl}piperazine-1-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C32H54N10O8 |
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| Mol. Mass. | 706.8334 |
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| SMILES | CC(C)(C)OC(=O)N1CCN(CC1)c1nc(nc2c(nc(nc12)N(CCO)CCO)N1CCN(CC1)C(=O)OC(C)(C)C)N(CCO)CCO |
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| Structure | 
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