| Reaction Details |
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 | Report a problem with these data |
| Target | Equilibrative nucleoside transporter 1 |
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| Ligand | BDBM23638 |
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| Substrate/Competitor | BDBM23618 |
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| Meas. Tech. | Flow Cytometric Assay |
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| pH | 7.4±n/a |
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| Temperature | 295.15±n/a K |
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| Comments | 16.2 +/- 1.9 % Inhibition @ 10 uM. |
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| Citation |  Lin, W; Buolamwini, JK Synthesis, flow cytometric evaluation, and identification of highly potent dipyridamole analogues as equilibrative nucleoside transporter 1 inhibitors. J Med Chem50:3906-20 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Equilibrative nucleoside transporter 1 |
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| Name: | Equilibrative nucleoside transporter 1 |
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| Synonyms: | ENT1 | Equilibrative NBMPR-sensitive nucleoside transporter | Equilibrative Nucleoside Transporter 1 (ENT1) | Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter | Equilibrative nucleoside transporter 1 | Nucleoside transporter, es-type | S29A1_HUMAN | SLC29A1 | Solute carrier family 29 member 1 |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 50225.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 456 |
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| Sequence: | MTTSHQPQDRYKAVWLIFFMLGLGTLLPWNFFMTATQYFTNRLDMSQNVSLVTAELSKDA
QASAAPAAPLPERNSLSAIFNNVMTLCAMLPLLLFTYLNSFLHQRIPQSVRILGSLVAIL
LVFLITAILVKVQLDALPFFVITMIKIVLINSFGAILQGSLFGLAGLLPASYTAPIMSGQ
GLAGFFASVAMICAIASGSELSESAFGYFITACAVIILTIICYLGLPRLEFYRYYQQLKL
EGPGEQETKLDLISKGEEPRAGKEESGVSVSNSQPTNESHSIKAILKNISVLAFSVCFIF
TITIGMFPAVTVEVKSSIAGSSTWERYFIPVSCFLTFNIFDWLGRSLTAVFMWPGKDSRW
LPSLVLARLVFVPLLLLCNIKPRRYLTVVFEHDAWFIFFMAAFAFSNGYLASLCMCFGPK
KVKPAEAETAGAIMAFFLCLGLALGAVFSFLFRAIV
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| BDBM23638 |
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| BDBM23618 |
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| Name | BDBM23638 |
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| Synonyms: | 2-{[4,8-bis({4-azatricyclo[4.3.1.1^{3,8}]undecan-4-yl})-6-[(2-hydroxyethyl)amino]pyrimido[5,4-d][1,3]diazin-2-yl]amino}ethan-1-ol | Dipyridamole Analogue, 20 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H44N8O2 |
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| Mol. Mass. | 548.7228 |
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| SMILES | OCCNc1nc(N2CC3CC4CC(C3)CC2C4)c2nc(NCCO)nc(N3CC4CC5CC(C4)CC3C5)c2n1 |TLB:8:9:17.16.15:12,14:13:17:10.9.8.7,14:9:17:15.12.13,28:29:37.36.35:32,34:33:37:30.29.28.27,34:29:37:35.32.33,THB:26:27:37:35.32.33,6:7:17:15.12.13,7:16:12:10.9.14,27:36:32:30.29.34| |
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| Structure | 
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