| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-secretase 1 [1-460] |
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| Ligand | BDBM136800 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | FRET Assay |
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| IC50 | 0.700±n/a nM |
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| Citation |  Csjernyik, G; Karlstrom, S; Kers, A; Kolmodin, K; Nylof, M; Ohberg, L; Rakos, L; Sandberg, L; Sehgelmeble, F; Soderman, P; Swahn, B; Von Berg, S Compounds and their use as BACE inhibitors US Patent US9918985 Publication Date 3/20/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-secretase 1 [1-460] |
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| Name: | Beta-secretase 1 [1-460] |
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| Synonyms: | BACE | BACE1 | BACE1_HUMAN | Beta-secretase 1 (BACE1) | Beta-secretase 1 (aa 1-460) | KIAA1149 |
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| Type: | Protein |
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| Mol. Mass.: | 50987.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P56817[1-460] |
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| Residue: | 460 |
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| Sequence: | MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAY
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| BDBM136800 |
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| n/a |
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| Name | BDBM136800 |
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| Synonyms: | US10231967, Example 48-Isomer-5 | US8865911, 48 Isomer 2 | US9918985, Example 48 Isomer 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H24ClN3O2 |
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| Mol. Mass. | 409.909 |
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| SMILES | CC1=N[C@]2(C[C@H](Oc3ccc(cc23)-c2cccc(Cl)c2)[C@@H]2CCCOC2)N=C1N |r,c:30,t:1| |
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| Structure | 
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