| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-3 |
|---|
| Ligand | BDBM376684 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzyme Assay |
|---|
| IC50 | <10±n/a nM |
|---|
| Citation |  Vechorkin, O; Li, Y; Sokolsky, A; Wang, A; Zhu, W; Zhuo, J Heterocyclic compounds useful as pim kinase inhibitors US Patent US9920032 Publication Date 3/20/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase pim-3 |
|---|
| Name: | Serine/threonine-protein kinase pim-3 |
|---|
| Synonyms: | PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 35888.19 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q86V86 |
|---|
| Residue: | 326 |
|---|
| Sequence: | MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI
ADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFL
LVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDL
RSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVC
GDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGV
PESCDLRLCTLDPDDVASTTSSSESL
|
|
|
|---|
| BDBM376684 |
|---|
| n/a |
|---|
| Name | BDBM376684 |
|---|
| Synonyms: | N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridin-3-yl}-3-(2-cyanophenyl)-5-fluoroquinoline-8-carboxamide | US10450296, Example 17 | US11053215, Example 17 | US9920032, Example 17 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H26FN5O |
|---|
| Mol. Mass. | 479.548 |
|---|
| SMILES | C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)-c1ccccc1C#N |r| |
|---|
| Structure | 
|
|---|
Search and Browse
