Ki Summary

Reaction Details

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Target

Serine/threonine-protein kinase pim-3

Ligand

BDBM377223

Substrate/Competitor

n/a

Meas. Tech.

Pim Enzyme Assays

IC50

<100±n/a nM

Citation

Xue, C; Feng, H; Li, Y; Zhang, K Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors US Patent US10265307 Publication Date 4/23/2019

More Info.:

Get all data from this article, Assay Method

Serine/threonine-protein kinase pim-3

Name:

Serine/threonine-protein kinase pim-3

Synonyms:

PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)

Type:

Protein

Mol. Mass.:

35888.19

Organism:

Homo sapiens (Human)

Description:

Q86V86

Residue:

326

Sequence:

MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI
ADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFL
LVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDL
RSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVC
GDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGV
PESCDLRLCTLDPDDVASTTSSSESL

BDBM377223

n/a

Name

BDBM377223

Synonyms:

US10265307, Example 59-2 | US10517858, Example 59 (Diastereoisomer 2) | US10828290, Example 59 (Diastereoisomer 2) | US11229631, Example 59 Diastereoisomer 2

Type

Small organic molecule

Emp. Form.

C26H26F3N5O3S

Mol. Mass.

545.577

SMILES

CS(=O)c1cc(F)c(c(F)c1)-c1nc(ccc1F)C(=O)Nc1cnc2[C@H](O)CCc2c1N1CCC[C@H](N)C1 |r,wU:35.39,wD:25.27,(5.19,6.76,;3.85,5.99,;2.52,6.76,;3.85,4.45,;2.52,3.68,;2.52,2.14,;1.18,1.37,;3.85,1.37,;5.19,2.14,;6.52,1.37,;5.19,3.68,;3.85,-.17,;2.52,-.94,;2.52,-2.48,;3.85,-3.25,;5.19,-2.48,;5.19,-.94,;6.52,-.17,;1.18,-3.25,;1.18,-4.79,;-.15,-2.48,;-1.48,-3.25,;-1.48,-4.79,;-2.82,-5.56,;-4.15,-4.79,;-5.61,-5.27,;-6.01,-6.76,;-6.52,-4.02,;-5.61,-2.78,;-4.15,-3.25,;-2.82,-2.48,;-2.82,-.94,;-1.48,-.17,;-1.48,1.37,;-2.82,2.14,;-4.15,1.37,;-5.48,2.14,;-4.15,-.17,)|

Structure