Reaction Details |
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Target | Solute carrier family 22 member 12 |
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Ligand | BDBM377700 |
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Substrate/Competitor | n/a |
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Meas. Tech. | URAT1 (Urate Anion Transporter) Inhibition Activity Assay |
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IC50 | 14.0±n/a nM |
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Citation | Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y Carboxy substituted (hetero) aromatic ring derivatives and preparation method and uses thereof US Patent US10266496 Publication Date 4/23/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Solute carrier family 22 member 12 |
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Name: | Solute carrier family 22 member 12 |
Synonyms: | OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1) |
Type: | Enzyme |
Mol. Mass.: | 59638.65 |
Organism: | Homo sapiens (Human) |
Description: | Q96S37 |
Residue: | 553 |
Sequence: | MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ
ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW
VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY
LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG
FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW
RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF
GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI
LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA
ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATH
GTLGNSVLKSTQF
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BDBM377700 |
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n/a |
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Name | BDBM377700 |
Synonyms: | US10266496, Example 27 |
Type | Small organic molecule |
Emp. Form. | C16H8ClNO4 |
Mol. Mass. | 313.692 |
SMILES | OC(=O)c1ccc(cc1O)-c1cc(cc2oc(Cl)cc12)C#N |
Structure |
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