| Reaction Details |
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 | Report a problem with these data |
| Target | A disintegrin and metalloproteinase with thrombospondin motifs 5 [262-930,L692P] |
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| Ligand | BDBM24010 |
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| Substrate/Competitor | BDBM23993 |
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| Meas. Tech. | ADAMTS-5 Inhibition Assay |
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| IC50 | 2400±n/a nM |
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| Citation |  Bursavich, MG; Gilbert, AM; Lombardi, S; Georgiadis, KE; Reifenberg, E; Flannery, CR; Morris, EA 5'-Phenyl-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (aggrecanase-2). Bioorg Med Chem Lett17:5630-3 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| A disintegrin and metalloproteinase with thrombospondin motifs 5 [262-930,L692P] |
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| Name: | A disintegrin and metalloproteinase with thrombospondin motifs 5 [262-930,L692P] |
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| Synonyms: | A disintegrin and metalloproteinase with thrombospondin motifs 5 | ADAM-TS 11 | ADAMTS-5 (Aggrecanase-2) | ADAMTS11 | ADAMTS5 | ADMP-2 | ADMP2 | ATS5_HUMAN |
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| Type: | Metalloprotease |
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| Mol. Mass.: | 73728.14 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UNA0[262-930,L692P] |
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| Residue: | 669 |
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| Sequence: | SISRARQVELLLVADASMARLYGRGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVL
GDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGM
ADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKRLMSS
ILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQILGPEELPGQTYDATQQCNLTF
GPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKY
YSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPC
PPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFS
PKVTDGTECRPYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNKK
SKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDI
NGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKPLDVRYSFFVPKKSTPKVNS
VTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSA
FKQCLLKKC
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| BDBM24010 |
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| BDBM23993 |
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| Name | BDBM24010 |
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| Synonyms: | 5-bromo-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spiro[indole-3,2'-[1,3,4]thiadiazole]-2-one | thiadiazole derivative, 21 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H12BrN3O2S |
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| Mol. Mass. | 390.254 |
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| SMILES | COc1ccc(cc1)C1=NNC2(S1)C(=O)Nc1ccc(Br)cc21 |t:9| |
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| Structure | 
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