| Reaction Details |
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 | Report a problem with these data |
| Target | Proto-oncogene tyrosine-protein kinase Src [1-530] |
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| Ligand | BDBM378897 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Inhibition Assays |
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| IC50 | 139±n/a nM |
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| Citation |  Yang, S; Wei, Y 3-acetylenyl-pyrazole-pyrimidine derivative, and preparation method therefor and uses thereof US Patent US10266537 Publication Date 4/23/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Proto-oncogene tyrosine-protein kinase Src [1-530] |
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| Name: | Proto-oncogene tyrosine-protein kinase Src [1-530] |
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| Synonyms: | Proto-oncogene tyrosine-protein kinase Src (aa 1-530) | SRC | SRC1 | SRC_HUMAN | c-Src (aa 1-530) |
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| Type: | n/a |
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| Mol. Mass.: | 59200.93 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P12931[1-530] |
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| Residue: | 530 |
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| Sequence: | MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE
PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD
WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES
ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL
CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL
KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY
LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT
ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER
GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY
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| BDBM378897 |
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| n/a |
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| Name | BDBM378897 |
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| Synonyms: | US10266537, Compound 12 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H25F3N8O |
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| Mol. Mass. | 558.557 |
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| SMILES | CC(C)n1nc(C#Cc2cc(ccc2C)C(=O)Nc2cc(cc(c2)C(F)(F)F)-n2cnc(C)c2)c2c(N)ncnc12 |
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| Structure | 
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