Reaction Details |
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Target | Tyrosine-protein phosphatase non-receptor type 6 [205-595] |
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Ligand | BDBM24553 |
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Substrate/Competitor | BDBM13432 |
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Meas. Tech. | Phosphatase Activity Assay |
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IC50 | 74200±n/a nM |
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Citation | Lawrence, HR; Pireddu, R; Chen, L; Luo, Y; Sung, SS; Szymanski, AM; Yip, ML; Guida, WC; Sebti, SM; Wu, J; Lawrence, NJ Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds. J Med Chem51:4948-56 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Tyrosine-protein phosphatase non-receptor type 6 [205-595] |
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Name: | Tyrosine-protein phosphatase non-receptor type 6 [205-595] |
Synonyms: | HCP | Hematopoietic cell protein-tyrosine phosphatase | PTN6_HUMAN | PTP-1C | PTP1C | PTPN6 | Protein-Tyrosine Phosphatase SHP-1 | Protein-tyrosine phosphatase 1C | SH-PTP1 | Tyrosine-protein phosphatase non-receptor type 6 |
Type: | Protein phosphatase |
Mol. Mass.: | 44886.26 |
Organism: | Homo sapiens (Human) |
Description: | Human recombinant GST-fusion SHP-1 (205-595). |
Residue: | 391 |
Sequence: | AFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLE
GQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIAS
QGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGE
HDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLP
HAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQ
YKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNITYPPAMKNAHAKASRTSSKHKEDVY
ENLHTKNKREEKVKKQRSADKEKSKGSLKRK
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BDBM24553 |
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BDBM13432 |
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Name | BDBM24553 |
Synonyms: | 3-{2-[(3Z)-5-({[4-chloro-3-(trifluoromethyl)phenyl]methyl}sulfamoyl)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]hydrazin-1-yl}benzoic acid | Oxindole scaffold, 10r |
Type | Small organic molecule |
Emp. Form. | C23H16ClF3N4O5S |
Mol. Mass. | 552.91 |
SMILES | OC(=O)c1cccc(NN=C2C(=O)Nc3ccc(cc23)S(=O)(=O)NCc2ccc(Cl)c(c2)C(F)(F)F)c1 |w:9.8| |
Structure |
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