| Reaction Details |
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 | Report a problem with these data |
| Target | Transthyretin |
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| Ligand | BDBM383209 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Determination of Binding Constants of HITS to TTR |
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| Kd | 820±129.7 nM |
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| Citation |  Graef, IA; Alhamadsheh, MM Identification of stabilizers of multimeric proteins US Patent US10278929 Publication Date 5/7/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Transthyretin |
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| Name: | Transthyretin |
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| Synonyms: | ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR) |
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| Type: | Enzyme |
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| Mol. Mass.: | 15884.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P02766 |
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| Residue: | 147 |
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| Sequence: | MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDT
WEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDS
GPRRYTIAALLSPYSYSTTAVVTNPKE
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| BDBM383209 |
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| n/a |
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| Name | BDBM383209 |
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| Synonyms: | US10278929, Compound 5 | US11337935, Compound 5 |
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| Type | Small organic molecule |
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| Emp. Form. | C40H33Cl2N3O10S |
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| Mol. Mass. | 818.675 |
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| SMILES | OC(=O)c1ccccc1Nc1cc(Cl)c(OCCOCCOCCNC(=S)Nc2ccc3c(c2)C(=O)OC32c3ccc(O)cc3Oc3cc(O)ccc23)c(Cl)c1 |
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| Structure | 
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