| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carbonic anhydrase 3 |
|---|
| Ligand | BDBM10883 |
|---|
| Substrate/Competitor | BDBM10856 |
|---|
| Meas. Tech. | CA Inhibition Assay |
|---|
| pH | 7.4±n/a |
|---|
| Temperature | 298.15±n/a K |
|---|
| Ki | >200000±n/a nM |
|---|
| Citation |  Temperini, C; Cecchi, A; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct. Bioorg Med Chem Lett18:2567-73 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Carbonic anhydrase 3 |
|---|
| Name: | Carbonic anhydrase 3 |
|---|
| Synonyms: | CA-III | CA3 | CAH3_HUMAN | Carbonate dehydratase III | Carbonic Anhydrase III | Carbonic anhydrase | Carbonic anhydrase 3 (CA III) | Carbonic anhydrase III (CA III) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 29562.11 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Human cloned isozyme. |
|---|
| Residue: | 260 |
|---|
| Sequence: | MAKEWGYASHNGPDHWHELFPNAKGENQSPVELHTKDIRHDPSLQPWSVSYDGGSAKTIL
NNGKTCRVVFDDTYDRSMLRGGPLPGPYRLRQFHLHWGSSDDHGSEHTVDGVKYAAELHL
VHWNPKYNTFKEALKQRDGIAVIGIFLKIGHENGEFQIFLDALDKIKTKGKEAPFTKFDP
SCLFPACRDYWTYQGSFTTPPCEECIVWLLLKEPMTVSSDQMAKLRSLLSSAENEPPVPL
VSNWRPPQPINNRVVRASFK
|
|
|
|---|
| BDBM10883 |
|---|
| BDBM10856 |
|---|
| Name | BDBM10883 |
|---|
| Synonyms: | 4,5-dichlorobenzene-1,3-disulfonamide | CHEMBL17 | Dichlorophenamide | Dichlorophenamide (DCP) | Dichlorophenamide, DCP | Sulfonamide, 4 | US10172837, Dichlorphenamide | sulfonamide 4 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C6H6Cl2N2O4S2 |
|---|
| Mol. Mass. | 305.159 |
|---|
| SMILES | NS(=O)(=O)c1cc(Cl)c(Cl)c(c1)S(N)(=O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
