Reaction Details |
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Target | Carbonic anhydrase 5A, mitochondrial |
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Ligand | BDBM25900 |
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Substrate/Competitor | BDBM10856 |
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Meas. Tech. | CA Inhibition Assay |
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Ki | 917±n/a nM |
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Citation | Temperini, C; Cecchi, A; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct. Bioorg Med Chem Lett18:2567-73 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Carbonic anhydrase 5A, mitochondrial |
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Name: | Carbonic anhydrase 5A, mitochondrial |
Synonyms: | CA-VA | CA5 | CA5A | CAH5A_HUMAN | Carbonate dehydratase VA | Carbonic Anhydrase VA | Carbonic anhydrase 5A (CA VA) | Carbonic anhydrase 5A, mitochondrial | Carbonic anhydrase 5A, mitochondrial precursor | Carbonic anhydrase V | Carbonic anhydrase VA (CA VA) |
Type: | Enzyme |
Mol. Mass.: | 34755.54 |
Organism: | Homo sapiens (Human) |
Description: | Human (cloned) isozyme |
Residue: | 305 |
Sequence: | MLGRNTWKTSAFSFLVEQMWAPLWSRSMRPGRWCSQRSCAWQTSNNTLHPLWTVPVSVPG
GTRQSPINIQWRDSVYDPQLKPLRVSYEAASCLYIWNTGYLFQVEFDDATEASGISGGPL
ENHYRLKQFHFHWGAVNEGGSEHTVDGHAYPAELHLVHWNSVKYQNYKEAVVGENGLAVI
GVFLKLGAHHQTLQRLVDILPEIKHKDARAAMRPFDPSTLLPTCWDYWTYAGSLTTPPLT
ESVTWIIQKEPVEVAPSQLSAFRTLLFSALGEEEKMMVNNYRPLQPLMNRKVWASFQATN
EGTRS
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BDBM25900 |
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BDBM10856 |
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Name | BDBM25900 |
Synonyms: | 2-chloro-5-(1-hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzene-1-sulfonamide | Chlortalidone | Chlorthalidone | Chlorthalidone (1) | Hygroton | Phthalamudine | US10172837, Chlorthalidone |
Type | Small organic molecule |
Emp. Form. | C14H11ClN2O4S |
Mol. Mass. | 338.766 |
SMILES | NS(=O)(=O)c1cc(ccc1Cl)C1(O)NC(=O)c2ccccc12 |
Structure |
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