| Reaction Details |
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 | Report a problem with these data |
| Target | Proto-oncogene Wnt-1 |
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| Ligand | BDBM384596 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | The screening assay for Wnt activity |
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| EC50 | 223±n/a nM |
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| Citation |  KC, SK; Wallace, DM; Cao, J; Chiruta, C; Hood, J 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof US Patent US10285982 Publication Date 5/14/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Proto-oncogene Wnt-1 |
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| Name: | Proto-oncogene Wnt-1 |
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| Synonyms: | INT1 | Proto-oncogene Int-1 homolog | WNT1 | WNT1_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 41006.01 |
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| Organism: | Homo sapiens (human) |
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| Description: | P04628 |
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| Residue: | 370 |
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| Sequence: | MGLWALLPGWVSATLLLALAALPAALAANSSGRWWGIVNVASSTNLLTDSKSLQLVLEPS
LQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRG
CRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLF
GREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLR
AVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHKPPSPHDLVYFEKSPNFCT
YSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNC
THTRVLHECL
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| BDBM384596 |
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| n/a |
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| Name | BDBM384596 |
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| Synonyms: | US10285982, Compound 40 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H22FN7 |
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| Mol. Mass. | 463.5089 |
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| SMILES | CC(C)Nc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1cc2c(ccnc2[nH]1)-c1ccc(F)cc1 |
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| Structure | 
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