| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphodiesterase |
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| Ligand | BDBM384928 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PDE2 Assay B |
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| Ki | 0.150±n/a nM |
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| Citation |  Shen, D; Wang, D; Qian, X; Harper, B; Yang, M; Bo, Y Pyrimidinone amide compounds as PDE2 inhibitors US Patent US10285989 Publication Date 5/14/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphodiesterase |
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| Name: | Phosphodiesterase |
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| Synonyms: | PDE2A3 | Phosphodiesterase A3 (PDE2A3) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 105547.91 |
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| Organism: | Macaca mulatta (Rhesus macaque) |
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| Description: | n/a |
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| Residue: | 941 |
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| Sequence: | MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDI
SGLQRAVKEALSAVLPRVETVYTYLLDGESRLVCEDPPHELPQEGKVWEAIISQKRLGCN
GLGLSDLPGKPLARLVAPLAPHTQVLVIPLVDKEAGAVAAVILVHCGQLSDNEEWSLQAV
EKHTLVALRRVQALQQRRPSEAPQAVQNPPEGAVEDQKGGAAYTDRDRKILQLCGELYDL
DASSLQLKVLQYLQQETRASRCCLLLVSEDSLQLSCKVMGDKVLGEEISFPLTGCLGQVV
EDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTD
QDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITE
ARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPD
AYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAF
SIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDESTKLLHDGIQPVAAIDSNF
ASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMH
AFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYS
SEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDL
QKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAM
GNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPEAAELYERVASNREHWTKVSH
KFTIRGLPSNNSLDFLDEEYEVPDLDGTGAPINGCCSLDAE
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| BDBM384928 |
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| n/a |
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| Name | BDBM384928 |
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| Synonyms: | N-[(1R)-2- methyl-1-{4- [(trifluoromethyl) sulfanyl]phenyl} propyl]-6-oxo-2- pyrrolidin-1-yl-1,6- dihydropyrimidine- 4-carboxamide | US10285989, Example 147 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H23F3N4O2S |
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| Mol. Mass. | 440.482 |
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| SMILES | CC(C)[C@@H](NC(=O)c1cc(=O)[nH]c(n1)N1CCCC1)c1ccc(SC(F)(F)F)cc1 |r| |
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| Structure | 
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