| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase receptor TYRO3 |
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| Ligand | BDBM246852 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TAM Enzymatic Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 300±n/a nM |
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| Comments | extracted |
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| Citation |  Li, Y; Burns, DM Fused bicyclic 1,2,4-triazine compounds as TAM inhibitors US Patent US9708333 Publication Date 7/18/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase receptor TYRO3 |
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| Name: | Tyrosine-protein kinase receptor TYRO3 |
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| Synonyms: | BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY |
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| Type: | Protein |
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| Mol. Mass.: | 96894.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q06418 |
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| Residue: | 890 |
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| Sequence: | MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPV
KLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVE
DGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKI
GGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSN
ASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRC
ANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKL
SWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQ
GPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAA
RSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQE
DGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPM
VILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARN
CMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGV
TMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFT
CLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAV
GGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
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| BDBM246852 |
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| n/a |
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| Name | BDBM246852 |
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| Synonyms: | ((2R,5S)-5-{2-[(1R)- 1-hydroxyethyl]-1H- imidazo[4,5- d]thieno[3,2- b]pyridin-1- yl}tetrahydro-2H- pyran-2- yl)acetonitrile | US10053465, 1 | US10065963, Compound 1 | US10125150, Example 1 | US10370387, Example 20 | US10479803, Example 1D | US10519163, Example 1 | US10675284, Example 1 | US11084822, Example 1 | US11130767, # 1 | US11161855, Example 20 | US11304949, Compound 5 | US11324749, Comp. No. 5 | US11406640, Comp. No. 5 | US11596632, Comp. No. 5 | US20240058343, Compound 5 | US9732097, Example 1 | US9777017, Example 20 | US9908895, Example 20 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H18N4O2S |
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| Mol. Mass. | 342.415 |
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| SMILES | C[C@@H](O)c1nc2cnc3ccsc3c2n1[C@H]1CC[C@H](CC#N)OC1 |r| |
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| Structure | 
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