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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase receptor TYRO3 | ||
| Ligand | BDBM246853 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | TAM Enzymatic Assay | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 300±n/a nM | ||
| Comments | extracted | ||
| Citation |  Li, Y; Burns, DM Fused bicyclic 1,2,4-triazine compounds as TAM inhibitors US Patent US9708333 Publication Date 7/18/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase receptor TYRO3 | |||
| Name: | Tyrosine-protein kinase receptor TYRO3 | ||
| Synonyms: | BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY | ||
| Type: | Protein | ||
| Mol. Mass.: | 96894.13 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q06418 | ||
| Residue: | 890 | ||
| Sequence: |
| ||
| BDBM246853 | |||
| n/a | |||
| Name | BDBM246853 | ||
| Synonyms: | 4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,1'H-4,4'- bipyrazol-1- yl)azetidin-1-yl]-2,5- difluoro-N-[(1S)- 2,2,2-trifluoro-1- methylethyl] benzamide | US10053465, 2 | US10065963, Compound 2 | US10125150, Example 2 | US10336759, # 2 | US10435392, Example 17 | US10479803, Example 2D | US10519163, Example 2 | US10675284, Example 2 | US11084822, Example 2 | US11130767, # 2 | US11136326, Example 2 | US11304949, Compound 4 | US11324749, Comp. No. 4 | US11591318, Example 7 | US11596632, Comp. No. 4 | US20240058343, Compound 4 | US9732097, Example 2 | US9926301, Example 17 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H22F5N7O | ||
| Mol. Mass. | 507.4591 | ||
| SMILES | C[C@H](NC(=O)c1cc(F)c(cc1F)N1CC(CC#N)(C1)n1cc(cn1)-c1c(C)n[nH]c1C)C(F)(F)F |r| | ||
| Structure | 
| ||