| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Mer |
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| Ligand | BDBM246864 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TAM Enzymatic Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | <100±n/a nM |
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| Comments | extracted |
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| Citation |  Li, Y; Burns, DM Fused bicyclic 1,2,4-triazine compounds as TAM inhibitors US Patent US9708333 Publication Date 7/18/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase Mer |
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| Name: | Tyrosine-protein kinase Mer |
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| Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer |
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| Type: | PROTEIN |
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| Mol. Mass.: | 110234.77 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1498723 |
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| Residue: | 999 |
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| Sequence: | MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQ
PALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVP
NIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKIN
NEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNE
QPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSI
LISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVS
CMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGY
RISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFI
PAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTE
EDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGS
VMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMS
SQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFL
HRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSK
SDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTD
PLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPD
SIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGE
RLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
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| BDBM246864 |
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| n/a |
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| Name | BDBM246864 |
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| Synonyms: | 3-(1- [1,3]oxazolo[5,4- b]pyridin-2- ylpyrrolidin-3-yl)-3- [4-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)- 1H-pyrazol-1- yl]propanenitrile | US10053465, 4 | US10065963, Compound 4 | US10125150, Example 4 | US10336759, # 4 | US10479803, Example 4 | US10519163, Example 4 | US10675284, Example 4 | US11084822, Example 4 | US11130767, # 4 | US11136326, Example 4 | US11304949, Compound 7 | US11324749, Comp. No. 7 | US11406640, Comp. No. 7 | US11596632, Comp. No. 7 | US20240058343, Compound 7 | US9732097, Example 4 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H19N9O |
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| Mol. Mass. | 425.446 |
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| SMILES | N#CCC(C1CCN(C1)c1nc2cccnc2o1)n1cc(cn1)-c1ncnc2[nH]ccc12 |
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| Structure | 
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