| Reaction Details |
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 | Report a problem with these data |
| Target | Epidermal growth factor receptor [696-1022,T790M,L858R] |
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| Ligand | BDBM26105 |
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| Substrate/Competitor | BDBM10852 |
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| Meas. Tech. | Fluorescence Binding Assay |
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| pH | 7.4±n/a |
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| Temperature | 295.15±n/a K |
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| Kd | 18.6±.5 nM |
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| Citation |  Yun, CH; Mengwasser, KE; Toms, AV; Woo, MS; Greulich, H; Wong, KK; Meyerson, M; Eck, MJ The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP. Proc Natl Acad Sci U S A105:2070-5 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Epidermal growth factor receptor [696-1022,T790M,L858R] |
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| Name: | Epidermal growth factor receptor [696-1022,T790M,L858R] |
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| Synonyms: | EGF-R Tyrosine Kinase Mutant (L858R/T790M) | EGFR | EGFR_HUMAN | ERBB | ERBB1 | HER1 |
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| Type: | Tyrosine-protein kinase |
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| Mol. Mass.: | 37326.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00533[696-1022,T790M,L858R] |
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| Residue: | 327 |
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| Sequence: | GEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKA
NKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLL
NWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGK
VPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQ
PPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDS
NFYRALMDEEDMDDVVDADEYLIPQQG
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| BDBM26105 |
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| BDBM10852 |
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| Name | BDBM26105 |
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| Synonyms: | 6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine | AEE788 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H32N6 |
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| Mol. Mass. | 440.5832 |
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| SMILES | CCN1CCN(Cc2ccc(cc2)-c2cc3c(N[C@H](C)c4ccccc4)ncnc3[nH]2)CC1 |r| |
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| Structure | 
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