| Reaction Details |
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 | Report a problem with these data |
| Target | Aurora kinase B |
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| Ligand | BDBM26306 |
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| Substrate/Competitor | Biotinylated Peptide Substrate |
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| Meas. Tech. | Aurora B Kinase Inhibition Assay |
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| pH | 7.5±n/a |
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| Temperature | 295.15±n/a K |
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| Ki | 1±n/a nM |
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| Citation |  Foote KM; Mortlock AA; Heron NM; Jung FH; Hill GB; Pasquet G; Brady MC; Green S; Heaton SP; Kearney S; Keen NJ; Odedra R; Wedge SR; Wilkinson RW Synthesis and SAR of 1-acetanilide-4-aminopyrazole-substituted quinazolines: selective inhibitors of Aurora B kinase with potent anti-tumor activity. Bioorg Med Chem Lett 18:1904-9 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Aurora kinase B |
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| Name: | Aurora kinase B |
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| Synonyms: | AIM-1 | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | Serine/threonine-protein kinase aurora B |
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| Type: | Protein |
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| Mol. Mass.: | 39327.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96GD4 |
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| Residue: | 344 |
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| Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
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| BDBM26306 |
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| Biotinylated Peptide Substrate |
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| Name: | Biotinylated Peptide Substrate |
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| Synonyms: | n/a |
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| Type: | Peptide |
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| Mol. Mass.: | 2374.22 |
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| Organism: | n/a |
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| Description: | n/a |
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| Residue: | 20 |
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| Sequence: | biotinyl-Ahx-tetra(LRRWSLG)
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