Reaction Details |
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Target | Plasma kallikrein |
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Ligand | BDBM263282 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibitory Activity Assay |
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IC50 | 9.61±0 nM |
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Citation | Davie, RL; Edwards, HJ; Evans, DM; Hodgson, ST; Miller, I; Novak, AR; Smith, AJ; Stocks, MJ Heterocyclic derivates US Patent US9533987 Publication Date 1/3/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Plasma kallikrein |
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Name: | Plasma kallikrein |
Synonyms: | Fletcher factor | KLK3 | KLKB1 | KLKB1_HUMAN | Kallikrein | Kininogenin | Plasma kallikrein heavy chain | Plasma kallikrein light chain | Plasma prekallikrein |
Type: | Protein |
Mol. Mass.: | 71391.16 |
Organism: | Homo sapiens (Human) |
Description: | P03952 |
Residue: | 638 |
Sequence: | MILFKQATYFISLFATVSCGCLTQLYENAFFRGGDVASMYTPNAQYCQMRCTFHPRCLLF
SFLPASSINDMEKRFGCFLKDSVTGTLPKVHRTGAVSGHSLKQCGHQISACHRDIYKGVD
MRGVNFNVSKVSSVEECQKRCTSNIRCQFFSYATQTFHKAEYRNNCLLKYSPGGTPTAIK
VLSNVESGFSLKPCALSEIGCHMNIFQHLAFSDVDVARVLTPDAFVCRTICTYHPNCLFF
TFYTNVWKIESQRNVCLLKTSESGTPSSSTPQENTISGYSLLTCKRTLPEPCHSKIYPGV
DFGGEELNVTFVKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDGSPTRI
AYGTQGSSGYSLRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCG
GSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEG
NHDIALIKLQAPLNYTEFQKPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNI
PLVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGE
GCARREQPGVYTKVAEYMDWILEKTQSSDGKAQMQSPA
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BDBM263282 |
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n/a |
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Name | BDBM263282 |
Synonyms: | 1-[6-((s)-3-fluoro-pyrrolidin-1-yl)-pyridin-3-ylmethyl]-3-trifluoromethyl-1h-pyrazole-4-carboxylic acid (1-amino-isoquinolin-6-ylmethyl)-amide | US9533987, example 60 |
Type | Small organic molecule |
Emp. Form. | C25H23F4N7O |
Mol. Mass. | 513.49 |
SMILES | Nc1nccc2cc(CNC(=O)c3cn(Cc4ccc(nc4)N4CC[C@H](F)C4)nc3C(F)(F)F)ccc12 |
Structure |
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