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TargetDisintegrin and metalloproteinase domain-containing protein 17
LigandBDBM26806
Substrate/CompetitorTACE substrate peptide
Meas. Tech.Enzyme Inhibition Assay
pH7.5±n/a
Temperature298.15±n/a K
IC50 1.4±n/a nM
CommentsMMP-1,-2,-9 Ki (nM) >4948, >3333, >2128.
Citation Ott, GR; Asakawa, N; Lu, Z; Anand, R; Liu, RQ; Covington, MB; Vaddi, K; Qian, M; Newton, RC; Christ, DD; Trzaskos, JM; Duan, JJ Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents. Bioorg Med Chem Lett18:1577-82 (2008) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Disintegrin and metalloproteinase domain-containing protein 17
Name:Disintegrin and metalloproteinase domain-containing protein 17
Synonyms:A disintegrin and metalloproteinase domain 17 | ADA17_PIG | ADAM 17 | ADAM17 | Snake venom-like protease | TACE | TNF-alpha-Converting Enzyme
Type:Metalloprotease
Mol. Mass.:12197.99
Organism:Sus scrofa (pig)
Description:Partially purified TACE was obtained from porcine spleen.
Residue:112
Sequence:
MLREQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPIGK
KNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM26806
TACE substrate peptide
Name:TACE substrate peptide
Synonyms:n/a
Type:Internally quenched peptide
Mol. Mass.:4119.10
Organism:n/a
Description:MCA, (7-methoxycoumarin-4-yl)acetyl. Dpa, N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl.
Residue:39
Sequence:
MCA-Pro-Leu-Ala-Gln-Ala-Val-Dpa-Arg-Ser-Ser-Ser-Arg-NH2