| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase FRK |
|---|
| Ligand | BDBM387836 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Kinase Screening Assay |
|---|
| IC50 | <10.00±n/a nM |
|---|
| Citation |  Unciti-Broceta, A; Fraser, C; O. Carragher, N Compounds US Patent US10294227 Publication Date 5/21/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase FRK |
|---|
| Name: | Tyrosine-protein kinase FRK |
|---|
| Synonyms: | FRK | FRK_HUMAN | FYN-related kinase | Nuclear tyrosine protein kinase RAK | PTK5 | RAK | SRC | Tyrosine Kinase FRK |
|---|
| Type: | Tyrosine-protein kinase |
|---|
| Mol. Mass.: | 58254.41 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P42685 |
|---|
| Residue: | 505 |
|---|
| Sequence: | MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAED
LSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGA
IGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRR
RIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRL
GSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLED
PIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNV
LVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFG
ILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTF
ETLRWKLEDYFETDSSYSDANNFIR
|
|
|
|---|
| BDBM387836 |
|---|
| n/a |
|---|
| Name | BDBM387836 |
|---|
| Synonyms: | US10294227, Code 585 | tert-butyl N-[4-[4-amino-1-[2-(4-methoxy-1-piperidyl)ethyl]pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxy-phenyl]carbamate (593) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H35N7O4 |
|---|
| Mol. Mass. | 497.5899 |
|---|
| SMILES | COC1CCN(CCn2nc(-c3ccc(NC(=O)OC(C)(C)C)c(OC)c3)c3c(N)ncnc23)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
