| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Yes |
|---|
| Ligand | BDBM50184781 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Screening Assay |
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| IC50 | <10.00±n/a nM |
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| Citation |  Unciti-Broceta, A; Fraser, C; O. Carragher, N Compounds US Patent US10294227 Publication Date 5/21/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Tyrosine-protein kinase Yes |
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| Name: | Tyrosine-protein kinase Yes |
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| Synonyms: | Proto-oncogene c-Yes | VHL/Tyrosine-protein kinase Yes | YES | YES1 | YES_HUMAN | p61-yes |
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| Type: | Protein |
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| Mol. Mass.: | 60801.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07947 |
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| Residue: | 543 |
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| Sequence: | MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMT
PFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQI
INNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRG
IFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHY
TEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT
KVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFL
KEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARL
IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNRE
VLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPG
ENL
|
|
|
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| BDBM50184781 |
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| n/a |
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| Name | BDBM50184781 |
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| Synonyms: | CHEMBL3823543 | US10294227, Code 533 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H36N8O |
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| Mol. Mass. | 500.6384 |
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| SMILES | COc1cc(ccc1NCc1ccccc1)-c1nn(CCN2CCC(CC2)N(C)C)c2ncnc(N)c12 |
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| Structure | 
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