Reaction Details |
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Target | Carbonic anhydrase 5A, mitochondrial |
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Ligand | BDBM26998 |
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Substrate/Competitor | BDBM10856 |
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Meas. Tech. | CA Inhibition Assay |
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pH | 7.5±n/a |
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Temperature | 293.15±n/a K |
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Ki | 763±n/a nM |
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Citation | Temperini, C; Cecchi, A; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference. Bioorg Med Chem17:1214-21 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Carbonic anhydrase 5A, mitochondrial |
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Name: | Carbonic anhydrase 5A, mitochondrial |
Synonyms: | CA-VA | CA5 | CA5A | CAH5A_HUMAN | Carbonate dehydratase VA | Carbonic Anhydrase VA | Carbonic anhydrase 5A (CA VA) | Carbonic anhydrase 5A, mitochondrial | Carbonic anhydrase 5A, mitochondrial precursor | Carbonic anhydrase V | Carbonic anhydrase VA (CA VA) |
Type: | Enzyme |
Mol. Mass.: | 34755.54 |
Organism: | Homo sapiens (Human) |
Description: | Human (cloned) isozyme |
Residue: | 305 |
Sequence: | MLGRNTWKTSAFSFLVEQMWAPLWSRSMRPGRWCSQRSCAWQTSNNTLHPLWTVPVSVPG
GTRQSPINIQWRDSVYDPQLKPLRVSYEAASCLYIWNTGYLFQVEFDDATEASGISGGPL
ENHYRLKQFHFHWGAVNEGGSEHTVDGHAYPAELHLVHWNSVKYQNYKEAVVGENGLAVI
GVFLKLGAHHQTLQRLVDILPEIKHKDARAAMRPFDPSTLLPTCWDYWTYAGSLTTPPLT
ESVTWIIQKEPVEVAPSQLSAFRTLLFSALGEEEKMMVNNYRPLQPLMNRKVWASFQATN
EGTRS
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BDBM26998 |
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BDBM10856 |
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Name | BDBM26998 |
Synonyms: | 6-chloro-3-(dichloromethyl)-1,1-dioxo-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide | TRICHLORMETHIAZIDE | trichloromethiazide, 6 |
Type | Small organic molecule |
Emp. Form. | C8H8Cl3N3O4S2 |
Mol. Mass. | 380.656 |
SMILES | NS(=O)(=O)c1cc2c(NC(NS2(=O)=O)C(Cl)Cl)cc1Cl |
Structure |
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